This paper introduces a framework of practical entry points at the national and local level for addressing climate change adaptation and resilience and maps them across the agriculture value chain and non-farming options in South Asia. The paper also identifies and discusses the critical challenges and knowledge gaps that currently exist in interacting and working with governments and organisations across these four main entry points. The paper then goes on to explore the conceptual framework by presenting examples of climate-resilient agriculture (CRA) interventions developed and deployed across the four entry points by the ACT programme. This provides a high-resolution picture of how the programme has designed and operationalised its interventions across the four entry points, to demonstrate the effectiveness of the CRA framework. Finally, the paper discusses a set of cross-cutting lessons derived from this review of the state of global practice on CRA and initiatives undertaken by the ACT programme.