The Global Water Security & Sanitation Partnership (GWSP) was launched in 2017 as an international partnership to support countries to meet the targets related to water and sanitation under the Sustainable Development Goals (SDGs), particularly those of Goal 6. GWSP provides client countries, other development partners, and World Bank staff with global knowledge, innovations and country-level technical support while also leveraging World Bank Group resources and financial instruments. This report describes GWSP’s results and the impact it has made over fiscal year 2021, the 12 months from July 2020 through June 2021. Despite a complex set of challenges, GWSP continued to provide support to governments as they face a triple crisis: achieving the SDGs, responding to the COVID-19 (coronavirus) pandemic, and tackling the effects of climate change. GWSP helped to make connections across sectors and provide an integrated and holistic set of solutions, in which building resilience to climate change and other shocks and stressors is fundamental. This year’s report presents the results achieved across GWSP's three business lines (water supply and sanitation, water resources management, and water in agriculture) as well as by the five themes that the Partnership addresses: inclusion, resilience, financing, institutions, and sustainability. The report also provides an overview of key issues in the water sector that GWSP has made extensive efforts to address, with notable results, including climate change; inclusion; urban sanitation; situations affected by fragility, conflict, and violence; and water supply, sanitation, and hygiene in healthcare facilities.