On average, Africa has reached the Millennium Development Goals horizon with remarkable performances in five of the eight Goals, even though not all five were fully achieved. The five Goals are: Goal 2 (Enrolment in primary education); Goal 3 (Gender equality and empowerment of women); Goal 4 (Child mortality reduction); Goal 6 (Combating the spread of HIV/AIDS, malaria and tuberculosis); and Goal 7 (Environmental sustainability). Notwithstanding the substantial human and financial efforts deployed for the realization of these achievements, the Goals remain an unfinished agenda, necessitating the adoption of bolder global and regional initiatives, such as the 2030 Agenda for Sustainable Development and Agenda 2063.