The Conference of the Parties (COP) to the Convention on Biological Diversity (CBD) will adopt, at its 15th meeting (COP-15), a framework that will guide the work on biodiversity at the global level for the period between now and 2030, towards the 2050 biodiversity vision of a world where biodiversity is valued, conserved, sustainably used and, as needed, restored. COP-15 will consider the draft post-2020 Global Biodiversity Framework (GBF) being developed by the Ad hoc Open-Ended Working Group on the post-2020 GBF (OEWG) with inputs from the CBD subsidiary bodies. The draft GBF is also supposed to have considered the lessons learned from the implementation of the Strategic Plan for Biodiversity 2011-2020 presented in the fifth edition of the Global Biodiversity Outlook (GBO-5). GBO-5 summarized the progress towards the Aichi Biodiversity Targets (ABT) and reviewed the successes and challenges in implementing the 2011-2020 Strategic Plan at the global level. As such, GBO-5 findings have major implications for the development of a successful post-2020 GBF. This document is the synthesis of the 6th national reports submitted by African countries with references to Agenda 2063 and the AfDB’s High Five. The document starts with an overview of progress towards national targets and uses that information to highlight the contributions of Africa to the achievement of each of the Aichi Biodiversity Targets contained in the Strategic Plan for Biodiversity 2011-2020.