The investigation on phytomedicine was conducted in order to asses the traditional uses and exact distribution of medicinal flora of arid areas of Pakistan. It was found that in a total of 59 plant species belonging to 50 genera and 30 families are reported to be used for different diseases as asthma, piles, cancer, skin diseases, as astringent, spermatorrhea, as refrigerant and diabetes. It was investigated that conservation of medicinally important plants and traditional folk knowledge is necessary in order to save them from extinction.