The study aimed to document and assess local knowledge on the use of insecticidal and insect repellent plants to manage disease-transmitting, nuisance and crop pests in Raya-Azebo district of Tigray region of Ethiopia. Ethnobotanical data were collected through semi-structured interviews conducted with purposively selected informants. Simple preference ranking exercises were conducted by ten informants to identify the most important insect repellent plants in the district. Samples of reported plants were collected, identified and deposited at the National Herbarium, Addis Ababa University.