High rates of climate and land-use changes threaten biodiversity and ecosystem function, creating a need for integrated assessments and planning at regional to global scales. We develop a new approach to measure multivariate estimates of climate and land-use change that builds on recently developed measures of climate velocity, and apply it to assess the combined speeds of climate and land use for the conterminous US from 2001 to 2051. The combined speeds of climate and land-use change are highest in a broad north-to-south swath in the central US and in parts of the inter mountain west.