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Nigeria: Vaccinologist Develops Immunogenic Experimental Ebola Vaccine

A vaccine developer from Nigeria, Dr Simon Agwale Friday in Paris, France, presented his progress report on Ebola vaccine saying that he "developed an EBOV candidate vaccine that is highly immunoge

Publication Date: 
02/06/2015
All Africa
Tags:
Health, Ebola Virus Disease ( Ebola Hemorrhagic Fever), Drugs, Epidemics, Infectious Diseases, Africa, Nigeria
Health

Interaction between TIM-1 and NPC1 is important for cellular entry of Ebola virus

Multiple host molecules are known to be involved in the cellular entry of filoviruses, including Ebola virus (EBOV); T-cell immunoglobulin and mucin domain 1 (TIM-1) and Niemann-Pick C1 (NPC1) have been identified as attachment and fusion receptors, respectively. However, the molecular mechanisms underlying the entry process have not been fully understood. We found that TIM-1 and NPC1 colocalized and interacted in the intracellular vesicles where EBOV glycoprotein (GP)-mediated membrane fusion occurred.

Publication Date: 
01/06/2015
Makoto Kuroda, Daisuke Fujikura, Asuka Nanbo & et al
Journal of Virology
89
12
6481-6493
Tags:
Ebola Virus Disease ( Ebola Hemorrhagic Fever), Research
Health

Harnessing case isolation and ring vaccination to control Ebola

As a devastating Ebola outbreak in West Africa continues, non-pharmaceutical control measures including contact tracing, quarantine, and case isolation are being implemented. In addition, public health agencies are scaling up efforts to test and deploy candidate vaccines. Given the experimental nature and limited initial supplies of vaccines, a mass vaccination campaign might not be feasible. However, ring vaccination of likely case contacts could provide an effective alternative in distributing the vaccine.

Publication Date: 
29/05/2015
Chad Wells, Dan Yamin, Martial L. Ndeffo-Mbah & et al
PLoS Neglected Tropical Diseases
Tags:
Ebola Virus Disease ( Ebola Hemorrhagic Fever), Vaccination, Liberia, Sierra Leone
Health

Sierra Leone: New Ebola Cases Spike in Guinea and Sierra Leone

Guinea and Sierra Leone have reported 35 new Ebola cases in the past week, four times as many as the week before, providing a reminder that the virus "will not go quietly", a top World Health Organ

Publication Date: 
21/05/2015
All Africa
Tags:
Health, Ebola Virus Disease ( Ebola Hemorrhagic Fever), Infectious Diseases, Epidemics, Guinea, Sierra Leone, Africa
Health

Nigeria, Seven Others to Begin Ebola Vaccine Trial

Abuja — Nigeria is one of eight African countries where clinical trials of a vaccine for the Ebola virus disease will soon commence.

Publication Date: 
21/05/2015
All Africa
Tags:
Health, Ebola Virus Disease ( Ebola Hemorrhagic Fever), Infectious Diseases, Vaccination, Epidemics, Nigeria, Africa
Health

Sierra Leone: Ebola Cases Rise in Guinea, Sierra Leone--WHO

The World Health Organisation (WHO), confirmed on Tuesday that Ebola has spread further in Guinea and Sierra Leone.

Publication Date: 
20/05/2015
All Africa
Tags:
Health, Ebola Virus Disease ( Ebola Hemorrhagic Fever), Infectious Diseases, Epidemics, Sierra Leone, Guinea, WHO, Africa
Health

Nigeria: WHO Sets Up U.S.$100 Million Ebola Fund

As the 68th Session of the World Health Assembly (WHA) opened in Geneva on Monday, the World Health Organisation (WHO) announced it was setting up a $100m contingency fund to mange any unexpected o

Publication Date: 
20/05/2015
All Africa
Tags:
Health, Ebola Virus Disease ( Ebola Hemorrhagic Fever), Infectious Diseases, Epidemics, Africa, WHO
Health

Liberia: Ebola Taskforce Ends School Safety Measures Study

At the conclusion of a civil society led assessment of safety protocols to the adherence of Ebola preventive measures in certain selected schools in Liberia, positive impressions have been noted ev

Publication Date: 
20/05/2015
All Africa
Tags:
Health, Ebola Virus Disease ( Ebola Hemorrhagic Fever), Infectious Diseases, Epidemics, Liberia, Africa
Health

Africa: New African Center to Tackle Infectious Diseases

Spurred on by the recent Ebola outbreak, an African Center for Disease Control and Prevention (CDC) is being established this year to effectively respond to major epidemics.

Publication Date: 
20/05/2015
All Africa
Tags:
Health, Infectious Diseases, Ebola Virus Disease ( Ebola Hemorrhagic Fever), Africa, Epidemics
Health

Liberia: Ebola Task Force Rejects 'Unprofessional' GAC Audit Report

Taking a page from President Ellen Johnson-Sirleaf, the Incident Management System or Task Force overseeing Liberia's response to the deadly Ebola virus outbreak, has characterized a recent audit b

Publication Date: 
19/05/2015
All Africa
Tags:
Health, Ebola Virus Disease ( Ebola Hemorrhagic Fever), Infectious Diseases, Epidemics, Liberia, Africa

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