Cissampelos pareira L. and Tinospora cordifolia (Willd.) Hook.f. & Thoms inhibited the propagation of rodent parasite Plasmodium berghei in vivo. In a typical fourday experiment, the BALB/c mice were administered with ethanol extracts of Cissampelos pareira L. and Tinospora cordifolia (Willd.) Hook.f. & Thoms. The parasitaemian in untreated control group ranged between 17.31% and 30.02% whereas the root extracts of Cissampelos pareira L. and stem extracts of Tinospora cordifolia (Willd.) Hook.f. & Thoms resulted in inhibition of Plasmodium berghei significantly. The inhibitory
properties of extracts of two plants require further studies so that the antimalarial activity is elucidated.