The Weather Research and Forecasting model with Chemistry (WRF/Chem) simulation with the 2005 Carbon Bond gas-phase mechanism coupled to the Modal for Aerosol Dynamics for Europe and the Volatility Basis Set approach for Secondary Organic Aerosol (SOA) are conducted over a domain in North America for 2006 and 2010 as part of the Air Quality Model Evaluation International Initiative (AQMEII) Phase 2 project. This paper focuses on comparison of model performance in 2006 and 2010 as well as analysis of the responses of air quality and meteorology–chemistry interactions to changes in emissions and meteorology from 2006 to 2010.