The case of the Pyramid Lake Paiute Tribe exemplifies tribal vulnerabilities as a result of climate change. Preliminary socio-economic data and analysis reveal that the tribe’s vulnerability to climate change is related to cultural and economic dependence on Pyramid Lake, while external socio-economic vulnerability factors influence adaptive capacity and amplify potential impacts. Reduced water supplies as a consequence of climate change would result in a compounded reduction of inflows to Pyramid Lake, thus potentially impacting the spawning and sustenance of a cultural livelihood, the endangered cui-ui fish (Chasmistes cujus).