This study addresses the extrapolation of in-situ glacier mass balance measurements to the mountain-range scale and aims at deriving time series of area-averaged mass balance and ice volume change for all glaciers in the European Alps for the period 1900–2100. Long-term mass balance series for 50 Swiss glaciers based on a combination of field data and modelling, and WGMS data for glaciers in Austria, France and Italy are used. A complete glacier inventory is available for the year 2003. Mass balance extrapolation is performed based on (1) arithmetic averaging, (2) glacier hypsometry, and (3) multiple regression. Given a sufficient number of data series, multiple regression with variables describing glacier geometry performs best in reproducing observed spatial mass balance variability. Future mass changes are calculated by driving a combined model for mass balance and glacier geometry with GCM ensembles based on four emission scenarios.