Dengue is the most important arthropod-borne viral infection of humans, it is established in the tropics worldwide, and its geographical expansion is expected to increase due to factors such as modern dynamics of climate change, globalization, travel, trade, poverty, unplanned urbanization, and viral evolution. The World Health Organization (WHO) estimates that 2.5 billion people are at risk of infection, with 50–100 million infections per year.

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