Warming-induced changes in lake thermal and mixing regimes present risks to water quality and ecosystem services provided by U.S. lakes and reservoirs. Modulation of responses by different physical and hydroclimatic settings are not well understood. We explore the potential effects of climate change on 27 lake “archetypes” representative of a range of lakes and reservoirs occurring throughout the U.S. Archetypes are based on different combinations of depth, surface area, and water clarity. LISSS, a one-dimensional dynamic thermal simulation model, is applied to assess lake response to multiple mid-21st century change scenarios applied to nine baseline climate series from different hydroclimatic regions of the U.S.