Climate change, interacting with changes in land use and demographics, will affect important human dimensions in the United States, especially those related to human health, settlements and welfare. The challenges presented by population growth, an aging population, migration patterns, and urban and coastal development will be affected by changes in temperature, precipitation, and extreme climate-related events. In the future, with continued global warming, heat waves and heavy downpours are very likely to further increase in frequency and intensity. This report focuses on impacts of global climate change, especially impacts on three broad dimensions of the human condition: human health, human settlements, and human welfare. It examines potential impacts of climate change on human society, opportunities for adaptation, and associated recommendations for addressing data gaps and near- and long-term research goals.