The PAN book was written to address the concerns of policy makers around the world who are faced with the need to replace the use of highly hazardous pesticides (HHPs) with safer and sustainable alternatives. Modern agroecological approaches to food production, together with many of the ecological practices that have evolved with farmers working alongside nature through hundreds of years, are proving to be sustainable, economically advantageous and good for food security. Successful cases of agroecological farming in Asia, Africa, Latin America, Europe and USA, presented in the book, substantiating the long-standing claim that ecological principles applied to agriculture are effective tools in the management of pests, including weeds, and provide sustainable livelihoods to farmers and rural communities. “The experiences in this book show how farmers using agroecological practices benefit from savings on agrochemical inputs and from improving their overall farm productivity. Getting better prices or market options for safer food helps farming households too. The case studies show that agroecological farming can improve food security and strengthen food sovereignty, while providing better adaptation to climate change and reducing harmful environmental impacts. The book also presents national and international policy recommendations designed to assist policy makers to implement the changes necessary to support widespread adoption of agroecology.