This document provides a crucial framework to enable water managers and policy makers to assess the impact of climate uncertainty and change on their water resources and work towards effective adaptation strategies. The multi-step process embraces a participatory, bottom-up approach to identify water security hazards, and is sensitive to indigenous and gender-related water vulnerabilities. By engaging local communities in the design of the analysis, the information provided by scientific modeling and climate analysis can be tailored and thus provide more useful answers to the challenges they are facing. They are also providing a more informed starting point to assess the different options for adaptation, and design robust adaptation pathways, in line with the local needs.