The relatively stable economic performance of Asia and the Pacific conceals increasing downside risks to regional progress in implementing the 2030 Agenda for Sustainable Development. In an era of uncertainty, bold and wise policies are needed to make growth inclusive and sustainable, i.e., “putting people and planet first.” A comprehensive assessment of the investment needed to reach the Sustainable Development Goals in the region by 2030 estimates an additional $1.5 trillion per year to end poverty and hunger, provide basic health care, a quality education, enabling infrastructure and clean energy for all, and for climate action and living in harmony with nature. These “ambitions beyond growth” are largely affordable for most countries in the region, given available public and private resources. Strong development partnerships and regional cooperation are essential to ensure that all countries complete this important journey.