An online survey was conducted by the Asia-Pacific Scientific and Technology Advisory Group (AP-STAG) in February 2022 to assess the implementation of the S&T Roadmap in the Asia-Pacific region and it was disseminated widely in various countries. A total of 145 responses were received from governments (at the national and local level), intergovernmental organizations, the United Nations and other stakeholders. The survey results indicate significant progress in many actions included in the S&T Roadmap, but more efforts are needed to reach the levels ‘Very Good’ and ‘Great’ in the implementation of these actions. There is increased interest in Priority for Action 4 and the least interest in Priority for Action 3. Overall, Priority for Action 3 and Priority for Action 4 were identified as having made the least progress among the four Priorities for Action. A regional status review was also provided for seven strategic themes, including (1) Science and synergies: sustainable development, climate change adaptation and disaster risk reduction, (2) The Sendai Framework and science and technology, (3) Localization and inclusivity: application of science and technology at the local level, (4) Cities, climate change and critical infrastructure, (5) Science, innovation and entrepreneurship, (6) Cascading (including NATECH), compound and systemic risks, and (7) Youth and innovation. This review was conducted through the analysis of challenges and gaps, opportunities and trends, and ways forward to accelerate S&T application for disaster risk reduction in the Asia-Pacific region.