This fourth annual progress report for the Global Action Plan for Healthy Lives and Well-being for All (SDG3 GAP) discusses what has worked and what has not worked since the SDG3 GAP was launched in 2019 and makes recommendations for the future. It also aims to inform thinking about how best to accelerate progress on the health-related Sustainable Development Goals (SDGs) ahead of the SDG Summit of the United Nations General Assembly and the high-level meeting on universal health coverage in September 2023.