Shanghai is a low-lying city (3–4 m elevation) surrounded on three sides by the East China Sea, the Yangtze River Estuary, and Hangzhou Bay. With a history of rapid changes in sea level and land subsidence, Shanghai is often plagued by extreme typhoon storm surges. The interaction of sea level rise, land subsidence, and storm surges may lead to more complex, variable, and abrupt disasters. In this paper, we used MIKE 21 models to simulate the combined effect of this disaster chain in Shanghai.