This paper investigates the chain of interactions between climatic change, drought condition and food production in Nigeria. The paper relied mainly on secondary data that were generated through the analysis of relevant data from government and non-governmental agencies. From these sources, both quantitative and qualitative information were collected depending on the immediate importance. Among other things, this paper addresses the estimate of drought condition in the savannah region of Nigeria, the nature of food production activities in the area and the extent to which continuous climatic change has affected the state of food production. The paper also examines the indigenous and formal institutional frameworks in addressing the situation for assured food security in Nigeria. The paper concludes from the findings that desertification has impacted negatively on the food production activities in the region, which has necessitated the intervention of the government through the assistance from the international development agencies to combat the problem.