The Apodi estuarine  located in the  north coast of Rio Grande do Norte State; it is a typical and key valley region with apparent upland ecosystem vulnerability and sensitivity. In order to  analyze  natural  and  eco­environmental  vulnerability,  remote  sensing  (RS)  and geographical  information  system  (GIS)  technologies  are  adopted  and  an  environmental numerical  model  is  developed  using  DIP  techniques.  The  objective  of  this  study  was  to improve  our  understanding  of  natural  and  eco­environmental  vulnerability;  it ?s  causes basically show the intensity, its distribution and human­environment effect on the ecosystem in  the  Apodi  estuarine,  so  that  a  strategy  of  sustainable  land  use  could  be  established.