Water characteristics of Kandla creek, monitored seasonally from 2002 to 2006 at four locations (mouth, cargo jetty, oil jetty and junction), indicated significant increases in nutrients, petroleum hydrocarbons (PHc) and phenols from anthropogenic additions, while increases in turbidity, total suspended solids (TSS) and salinity from natural effects. Principal Component Analyses (PCA) of the data indicated port activities contaminating the creek water by fall out from loading and unloading of fertilizer and raw materials; petroleum, oil and lubricants (POL) and the boat traffic. Strong macro tidal currents increase turbidity and TSS, while the high salinity water from creek tributaries formed from intense evaporation during summer, and the seepage of brines in the creek from nearby salt pans during monsoonal drainage increase the salinity of creek water.