Availability of clean water and adequate sanitation facilities are of prime importance for limiting diarrheal diseases. We examined the spatial information on the groundwater quality and sanitation facilities of a village in southern India using Geographic Information System (GIS) tools. Place of residence, position of wells and latrines were mapped and well water samples were tested for microbial contamination (Total Coliform Counts (TCC), Fecal Coliform Counts (FCC) and Fecal Streptococcal Counts (FSC)). A well structured questionnaire was administered to 50 residents of the selected areas to elicit information on water collection, handling and storage. The location and distances of wells from latrines were determined using the Global Positioning System (GPS) device and a tape rule respectively. Data on 170 cases of various water-borne diseases were collected from primary health centers in the study area. Groundwater in the village was found to be microbiologically unfit for consumption.