India has committed to reduce the carbon emissions intensity of its GDP by 45% by 2030 and to achieve net-zero emissions by 2070. Reducing heavy-duty truck emissions, which are a large and growing source of overall transport emissions, will be essential to meeting these goals. This paper assesses the rate of zero-emission truck (ZET) adoption necessary for India to meet its 2030 and 2070 climate targets. Considering various policy and market scenarios, it examines the impact of ZET penetration on the total fleet’s tank-to-wheel and well-to-wheel CO2 emissions. As India seeks to expand its production and use of green hydrogen, this paper also analyzes the impact of grey and green hydrogen uses on fleet-wide emissions.