Ongoing globalization has imposed challenges on the Central Asia Regional Economic Cooperation (CAREC) countries because of current transport and trade constraints. Thus, a transport and trade facilitation strategy and implementation action plan were prepared to develop an efficient transport and trade system, which is critical to sustain economic prosperity in the CAREC region for the next 10 years. This publication presents the major elements of the strategy and the action plan, both of which support broad-based activities comprising competitive corridor development and management, trade facilitation, and sustainability enhancement by improving infrastructure, management, and technology, focusing on the six major corridors of the CAREC region.