The frequency, duration, and intensity of cold waves are expected to decrease in the near future under the changing climate. However, there is a lack of understanding on future mortality related to cold waves. The present study conducted a large-scale national projection to estimate future mortality attributable to cold waves during 1960–2050 in 209 US cities.

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Rapid build-up of greenhouse gases is expected to increase Earth’s mean surface temperature, with unclear effects on temperature variability. This makes understanding the direct effects of a changing climate on human health more urgent. However, the effects of prolonged exposures to variable temperatures, which are important for understanding the public health burden, are unclear.

The association of particulate matter (PM) with cardiovascular morbidity and mortality is well documented. PM-induced ischemia is considered a potential mechanism linking PM to adverse cardiovascular outcomes.