The frequency, duration, and intensity of cold waves are expected to decrease in the near future under the changing climate. However, there is a lack of understanding on future mortality related to cold waves. The present study conducted a large-scale national projection to estimate future mortality attributable to cold waves during 1960–2050 in 209 US cities.

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Rapid build-up of greenhouse gases is expected to increase Earth’s mean surface temperature, with unclear effects on temperature variability. This makes understanding the direct effects of a changing climate on human health more urgent. However, the effects of prolonged exposures to variable temperatures, which are important for understanding the public health burden, are unclear.

Both short- and long-term exposures to fine particulate matter (PM2.5) are associated with mortality. However, whether the associations exist below the new EPA standards (12 μg/m3 of annual average PM2.5, 35 μg/m3 daily) is unclear. In addition, it is not clear whether results of previous time series studies (fit in larger cities) and cohort studies (fit in convenience samples) are generalizable to the general population. The objective of the study was to estimate the effects of low-concentration PM2.5 on mortality.