Health

Safety and effectiveness of Meropenem in infants with suspected or complicated intra-abdominal infections

Intra-abdominal infections are common in young infants and lead to significant morbidity and mortality. Meropenem is a broad-spectrum antimicrobial with excellent activity against pathogens associated with intra-abdominal infections. The purpose of this study was to determine the safety and effectiveness of meropenem in young infants with suspected or complicated intra-abdominal infections.

Original Source

Publication Date: 
01/12/2012
Michael Cohen-Wolkowiez, Brenda Poindexter, Margarita Bidegain & et al
Clinical Infectious Diseases
55
11
1495-1502
Tags:
Drugs, Child Health, Antibiotics, Micro Organisms, Medical Research, United States Of America (US)
Health

Population pharmacokinetics of meropenem in plasma and cerebrospinal fluid of infants with suspected or complicated intra-abdominal infections

Suspected or complicated intra-abdominal infections are common in young infants and lead to significant morbidity and mortality. Meropenem is a broad-spectrum antimicrobial agent with excellent activity against pathogens associated with intra-abdominal infections in this population. The purpose of this study was to determine the pharmacokinetics (PK) of meropenem in young infants as a basis for optimizing dosing and minimizing adverse events.

Original Source

Publication Date: 
01/10/2011
P. Brian Smith, Michael Cohen-Wolkowiez, Lisa M. Castro & et al
Pediatric Infectious Disease Journal
30
10
844–849
Tags:
Child Health, Micro Organisms, Infant mortality, Drugs, Medical Research, United States Of America (US), Antibiotics, Infectious Diseases