Prospective studies that evaluate the influence of arsenic methylation capacity on cardiovascular disease (CVD) risk are lacking. The objective of the study is to evaluate the association of arsenic exposure from drinking water and arsenic methylation capacity with CVD risk..

Exposure to inorganic arsenic (As) via drinking water has been linked to increased risk of skin cancer, internal cancers, and cardiovascular disease, and an association between diabetes mellitus and exposure to relatively high concentrations (> 500 ?g/L) of As in drinking water has been reported.