This publication showcases a compilation of project briefs culled from case studies of good practices, new approaches, and working models on sanitation and wastewater management from different countries. The project briefs demonstrate solution options from which useful lessons can be derived. Not only do they illustrate how sanitation and wastewater management challenges can be addressed, the project briefs also aim to inspire replication and show opportunities for actions and investments. Given the more complex water resource and health challenges in many parts of the world, it is time to engage in a rational analysis of all possible management strategies, learn from others’ experiences, apply innovative approaches, and tap potential markets.