This paper provides the climatic and biophysical context of three watersheds in northern Ghana - Anyari and Zanlerigu in the Upper East region and Bihinaayili in the Northern region. The objective of the study is to describe the agro-climatic and hydrological features of the watersheds from a landscape perspective, which can be used as baseline information for intended water management interventions towards agricultural intensification. The work builds on primary and secondary data to characterize the watersheds, including historic climate analysis, watershed delineation, soil and land cover mapping, soil and water quality analysis, and characterization of agricultural production systems.