This paper includes: a summary of the systemic nature of biodiversity loss and ecosystem degradation; Examples of biodiversity loss, ecosystem degradation and the associated value at risk; Current perceptions of biodiversity loss amongst business leaders and other decision makers; A typology of business risks related to biodiversity loss and ecosystem degradation including current examples and a case study looking at agricultural supply chains; and A high level guide for CEOs seeking to protect their businesses from the risks identified, pointing to a number of initiatives and resources that can help.