This paper raises the importance for the international community to understand and reduce loss and damage associated with the adverse effects of climate change, including impacts related to extreme weather events and slow onset events, in response to the increase in weather-related disasters. It warns that impacts of loss and damage due to weather extremes and longer-term climatological shifts can set back development and reinforce the cycle of poverty in developing countries, and comments on the Special Report on Managing the Risks of Extreme Events and Disasters to Advance Climate Change Adaptation (SREX) recently released by IPCC.