The sustainability of future water resources is of paramount importance and is affected by many factors, including population, wealth and climate. Inherent in current methods to estimate these factors in the future is the uncertainty of their prediction. In this study, we integrate a large ensemble of scenarios—internally consistent across economics, emissions, climate, and population—to develop a risk portfolio of water stress over a large portion of Asia that includes China, India, and Mainland Southeast Asia in a future with unconstrained emissions.