Megadroughts are comparable in severity to the worst droughts of the 20th century but are of much longer duration. A megadrought in the American Southwest would impose unprecedented stress on the limited water resources of the area, making it critical to evaluate future risks not only under different climate change mitigation scenarios but also for different aspects of regional hydroclimate. We find that changes in the mean hydroclimate state, rather than its variability, determine megadrought risk in the American Southwest.