The objectives of this paper are to assess the status of zero-emission HDV deployment and policies in Emerging Markets and Developing Economies (EMDEs), evaluate the major policy levers for HDV electrification, and identify policy barriers and key recommendations for HDV electrification in the EMDEs. This briefing was originally produced and used to inform the Regional Dialogue meetings held in March and April, 2022 regarding HDV electrification. Heavy-duty vehicles (HDVs) contribute a disproportionate share of emissions that destabilize the climate and jeopardize human health. By 2025, the global HDV fleet is projected to contribute more greenhouse gas emissions than the light-duty vehicle fleet. Zero-emission vehicle (ZEV) technology for HDVs, including battery electric vehicles and fuel-cell electric vehicles, has the potential to reduce significantly climate and air quality impacts, including in emerging markets and developing economies (EMDEs).