The latest Ebola virus (EBOV) epidemic spread rapidly through Guinea, Sierra Leone, and Liberia, creating a global public health crisis and accelerating the assessment of experimental therapeutics and vaccines in clinical trials. One of those vaccines is based on recombinant vesicular stomatitis virus expressing the EBOV glycoprotein (VSV-EBOV), a live-attenuated vector with marked preclinical efficacy. Here, we provide the preclinical proof that VSV-EBOV completely protects macaques against lethal challenge with the West African EBOV-Makona strain.

Detailed geodetic imaging of earthquake rupture enhances our understanding of earthquake physics and induced ground shaking. The April 25, 2015 Mw 7.8 Gorkha, Nepal earthquake is the first example of a large continental megathrust rupture beneath a high-rate (5 Hz) GPS network. We use GPS and InSAR data to model the earthquake rupture as a slip pulse of ~20 km width, ~6 s duration, and with peak sliding velocity of 1.1 m/s that propagated toward Kathmandu basin at ~3.3 km/s over ~140 km.

Poaching of elephants is now occurring at rates that threaten African populations with extinction. Identifying the number and location of Africa’s major poaching hotspots may assist efforts to end poaching and facilitate recovery of elephant populations. We genetically assign origin to 28 large ivory seizures (≥0.5 tons) made between 1996-2014, also testing assignment accuracy. Results suggest that the major poaching hotspots in Africa may be currently concentrated in as few as two areas.