Increasing levels of air pollutants in Asia have recently drawn considerable attention, but the effects of Asian pollution outflows on regional climate and global atmospheric circulation remain to be quantified. Using a multiscale global aerosol–climate model (GCM), we demonstrate long-range transport of the Asian pollution, large resulting variations in the aerosol optical depth, cloud droplet number concentration, and cloud and ice water paths; enhanced shortwave and longwave cloud radiative forcings; and increased precipitation and poleward heat transport. Our work provides, for the first time to the authors’ knowledge, a global multiscale perspective of the climatic effects of pollution outflows from Asia. The results reveal that the multiscale modeling framework is essential in simulating the aerosol invigoration effect of deep convective cloud systems by a GCM.