The efficient movement of goods and services is important in achieving sustainable development. All main modes of freight – road, water, air, and rail – have impacts on the economy, environment, and society that need to be managed. Freight trucks account for 24% of global carbon dioxide (CO2) emissions from transport vehicle use and also have a major impact on fuel use and fuel security, air pollution, traffic accidents, and HIV/AIDS. This paper focuses on the road freight sector as it is the dominant mode of freight in Asia. It is a sequel to the paper "Challenges and Opportunities for an Environmentally Sustainable Road Freight Sector in Asia" that was prepared for the 5th Regional Environmentally Sustainable Transport (EST) Forum in 2010.