This brief looks at food system innovations and digital technologies as important drivers of productivity growth and improved food and nutrition security. The analysis emphasizes a mix of research feasibility and technology-enabling policy factors necessary to realize pro-poor benefits. Given their transformative potential and the urgency of developing the enabling R&D and policy trajectories required for impact, highlight genome editing bio-innovations, specifically CRISPR-Cas9, to address sustainable agricultural growth; and digital technologies, including remote sensing, connected sensors, artificial intelligence, digital advisory services, digital financial services, and e-commerce, to help guide the operations and decision-making of farmers, traders, and policymakers in agricultural value chains. The analysis points to the need to close critical gaps in R&D investments, capabilities, and enabling policies as well as regulations to accelerate the scaling and adoption of innovations.