This report explores for the first time the scale of the challenge for 20 cities across the world to reach selected targets set out in the Sustainable Development Goals (SDGs). More than half of the targets included will require a profound acceleration of efforts if they are to be achieved by the majority of selected cities. Targets that are not on course to be met by the majority of cities studied include ending child malnutrition, achieving full and productive female employment, access to adequate housing and access to drinking water and sanitation.