Despite increasing recognition of the importance of ecosystem-based approaches for disaster risk reduction and climate change adaptation, implementation remains mostly underdeveloped worldwide. Lack of knowledge on the implementation process present an important barrier. This publication presents details on Ecosystems Protecting Infrastructure and Communities (EPIC), a global initiative which promoted ecosystem-based approaches for disaster risk reduction and climate change adaptation in six countries. The publication provides a detailed description of the project’s operational approach and draws lessons from the case studies to inform and guide best practices for actions on the ground.