MEASLES vaccine comes in powder form. It must be used immediately after it is mixed with a fluid, says Dr Jacob John, former professor of the Department of Clinical Microbiology and Virology . Multi-vial doses of these vaccines must be used within four hours; else they will act as a medium for growing bacteria that can secrete toxins, he says.

Four children, all below 10 months of age, died after being administered measles vaccine at Pennaloorpettai and Venkatapuram villages in Tiruvallur district near Chennai on Wednesday. Another 15 children have been hospitalised after developing anaphylaxis reaction after being administered the vaccine, sources in the Public Health Department said.

Aiming to achieve historic success by total eradication of polio from Pakistan, the government is intensifying schedule of supplementary immunisation activities to include four rounds of National Immunisation Days (NIDs) and four sub-national activities in 2008. The next campaign will commence from March 4. This was stated by the Extended Programme of Immunisation (EPI) manager, H.B. Memon, as he briefed the media persons here at an event organised by the United Nations Children Fund (Unicef). The strategy works in Pakistan, still one of the four countries globally that are still polio endemic, Mr Memon said. He said: "Before initiation of the programme the number of cases of polio was estimated to be about 25,000 to 30,000 a year. Some 230,000 children were saved from paralysis after NIDs were introduced in 1994. The number of cases dropped to 1,147 in 1997, 40 cases in 2006, 32 in 2007 and only two in 2008 (Nawabshah and Hyderabad).' Informing about the upcoming sub-national campaign, a total of 16.79 million children under five years of age would be targeted in 54 districts of the country. A total of 43,033 vaccination teams, 7,922 area supervisors and 1,296 zonal supervisors would participate in the campaign. The campaign activities will also be monitored by more than 500 national monitors. Stressing on increasing geographical restriction of wild polio virus, the EPI representative said the majority of districts had been polio free for almost two years. Sixty per cent of the cases in 2006 were from six districts only. There had been no cases from the Federally Administered Northern Areas (Fana) since 1998, Azad Jammu and Kashmir since 2000 or Islamabad since 2003. The vast majority of population, in both Pakistan and Afghanistan, lived in polio free areas, as wild polio virus transmission is currently focal in two main areas

Although vaccination has almost eliminated measles in parts of the world, the disease remains a major killer in some high birth rate countries of the Sahel. On the basis of measles dynamics for industrialized countries, high birth rate regions should experience regular annual epidemics. Here, however, we show that measles epidemics in Niger are highly episodic, particularly in the capital Niamey. Models demonstrate that this variability arises from powerful seasonality in transmission

as the Simlipal National Park in Orissa's Mayurbhanj district closes during monsoon to protect wildlife, it turns into a graveyard for its human inhabitants, reports an independent working group on

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Pakistan plans to boost its measles immunisation programme. The campaign may gain strong grounds under the Expanded Programme on Immunisation. Several non-governmental organisations and communities

measles , diarrhoea, and rabies have claimed 121 lives in Nepal in this year's rainy season. Three districts of the

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