Questions have been raised about the transparency and scientific quality of regulatory processes applied in the first open field releases of genetically modified (GM) insects, and there is concern that inappropriate precedents have been set, particularly through generic risk assessments covering multiple species and technologies.

Experimental releases of genetically modified (GM) insects are reportedly being evaluated in various countries, including Brazil, the Cayman Islands (United Kingdom), France, Guatemala, India, Malaysia, Mexico, Panama, Philippines, Singapore, Thailand, the United States of America, and Vietnam. GM mosquitoes (Aedes aegypti) have already been released for field trials into inhabited areas in the Cayman Islands (2009–?), Malaysia (2010–2011), and Brazil (2011–2012).