With limited land resources, inadequate energy supply, and growing water stress, South Asia faces the challenge of providing enough water and energy to grow enough food for the burgeoning population. Using secondary data from diverse sources, this paper explores the food, water, and energy nexus from a regional dimension, emphasizing the role of Hindu Kush Himalayan (HKH) ecosystem services in sustaining food, water, and energy security downstream. The analysis reveals that the issues and challenges in the food, water, and energy sectors are interwoven in many complex ways and cannot be managed effectively without cross-sectoral integration.