Urban residence is associated with a higher risk of some psychiatric disorders, but the underlying drivers remain unknown.

Widening polarization about political, religious, and scientific issues threatens open societies, leading to entrenchment of beliefs, reduced mutual understanding, and a pervasive negativity surrounding the very idea of consensus.

Working memory deficits are present in many neuropsychiatric diseases with diagnosis-related severity. However, it is unknown whether this common behavioral abnormality is a continuum explained by a neural mechanism shared across diseases or a set of discrete dysfunctions.

Use of tobacco products is injurious to health in men and women. However, tobacco use by pregnant women receives greater scrutiny because it can also compromise the health of future generations. More men smoke cigarettes than women. Yet the impact of nicotine use by men upon their descendants has not been as widely scrutinized.

The Sustainable Development Goals (SDGs) represent an exponential advance from the Millennium Development Goals, with a substantially broader agenda affecting all nations and requiring coordinated global actions.