Land degradation is as a result of broad range of scales and factors, which include biophysical, climatic, demographic and socio-economic. The aim of this paper was to provide an analysis of wetland utilisation, ecosystem degradation and their effect on the Lake Victoria (Kenya) ecosystem. This involved analysis of socioeconomic and remote sensed data. The main sources of wetland degradation in the Lake Victoria basin were identified as (1) farming activities, (2) grazing and macrophyte harvesting and (3) coupled with catchment degradation-deforestation.