Calculated loading rates of trace metals into the three environmental compartments demonstrate that human activities now have major impacts on the global and regional cycles of most of the trace elements. There is significant contamination of freshwater resources and an accelerating accumulation of toxic metals in the human food chain.

A great concern over genotoxic potential of environmental chemicals has been expressed in recent years. Endosulfan a polycyclic chlorinated hydrocarbon of cyclodien group, is a well known insecticide. It is widely used in agriculture and, in some countries, in public health.

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The insecticide endosulfan, has been widely used for the control of crop pests in the field of agriculture. Although no mutagenic, teratogenic or carcinogenicity information is available on this insecticide, there are several reports concerning its toxicity after oral as well as from repeated administration in mice, rats and rabbits.